Locating biospecimens

NACC has gathered data since 1984 on various tissues stored at the Alzheimer's Disease Research Centers (ADRCs) for their subjects. Some tissues are from autopsy, and some are from living subjects. Postmortem specimens include brain tissue (frozen, formalin-fixed, and paraffin-block) and CSF. Antemortem specimens include DNA, serum, and CSF. Clinical and pathological features characterizing the subjects who supplied tissue are defined in the MDS, UDS, or NP data forms or guidebooks.


Tissue location request form

To find specimens from the well characterized participants in NACC’s longitudinal UDS data set, you should submit a tissue location request, which draws primarily from data in NACC’s Neuropathology Data Set. When you submit a tissue location request, you provide NACC with a brief description of the type(s) of tissue you seek and any parameters needed to narrow your selection. NACC will search for ADRCs that may have your target tissues, and then put you in touch with those Centers.

Biospecimen Resource Locator Tool

On the other hand, if the specimens you seek need not be from NACC’s UDS participants, you should explore NACC’s NP & Biospecimen Resource Locator Tool, below. The tool contains information on specimens banked at the ADRCs from subjects that may or may not be represented in the UDS. The tool allows the user to filter by tissue type, neuropathologic disease, and so on, and provides contact information for those at the center responsible for biospecimen-sharing requests.


Please note that the tissues reported as stored at the ADRC may not reflect the Center’s current inventory, as tissue samples may be depleted over time or be unavailable for sharing. Thus, all estimates of availability are rough estimates.

Biospecimen locator

Neuropathological disease
Tissue type
Link to NACC data
Center
Contact
Vascular dementia/stroke
Spinal cord
No
Rush University
Vascular dementia/stroke
Spinal cord
No
University of California San Francisco
Vascular dementia/stroke
Spinal cord
Yes
Emory University
Vascular dementia/stroke
Spinal cord
Yes
Rush University
Vascular dementia/stroke
Spinal cord
Yes
University of California San Francisco
Vascular dementia/stroke
Spinal cord
Yes
University of Southern California
Vascular dementia/stroke
Other
No
Northwestern University
Vascular dementia/stroke
Other
No
Stanford University
Vascular dementia/stroke
Other
Yes
Northwestern University
Vascular dementia/stroke
Other
Yes
Stanford University
Vascular dementia/stroke
Other
Yes
University of Southern California
Vascular dementia/stroke
Nerve
No
Rush University
Vascular dementia/stroke
Nerve
Yes
Rush University
Vascular dementia/stroke
Muscle
No
Rush University
Vascular dementia/stroke
Muscle
Yes
Mount Sinai
Vascular dementia/stroke
Muscle
Yes
Rush University
Vascular dementia/stroke
Muscle
Yes
University of Southern California
Vascular dementia/stroke
Eyes
No
Unavailable
Vascular dementia/stroke
Eyes
Yes
Unavailable
Vascular dementia/stroke
Brain: Fresh frozen
No
Arizona ADRC
Vascular dementia/stroke
Brain: Fresh frozen
No
Emory University
Vascular dementia/stroke
Brain: Fresh frozen
No
Massachusetts ADRC
Vascular dementia/stroke
Brain: Fresh frozen
No
Mayo Clinic
Vascular dementia/stroke
Brain: Fresh frozen
No
New York University
Vascular dementia/stroke
Brain: Fresh frozen
No
Northwestern University
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If you’re unable to find what you’re looking for, please don’t hesitate to contact us.

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University of Washington

NACC is funded by the National Institute on Aging (U01 AG016976) and located in the Department of Epidemiology at the University of Washington School of Public Health, Walter A. Kukull, Ph.D., Director. © 2021 University of Washington