Best Practices
NACC maintains a library of best practice resources to support consistent, high-quality research across the Alzheimer's Disease Research Center (ADRC) network. Developed through collaboration with NIA-convened working groups, these resources address key aspects of center operations, from biospecimen handling and participant engagement to data management and institutional governance.
These resources are intended as practical guidance for new centers and any centers launching a new research line. They should not be construed as requirements for center activities.
Because many of these areas continue to evolve, we periodically review and update these guidelines. If you have suggestions for new topics or notice content that may be outdated, please use the feedback link at the bottom of this page.
Participant Engagement and Clinical Operations
These resources support participant-facing workflows, including enrollment, consent, and return of results.
- Biomarker Disclosure (CLIN, BIO)
- Consent / Confidentiality* (ADMIN, CLIN)
- Digital Voice Capture (CLIN)
- Recommendations for Inclusive Dementia Research Published (ORE, CLIN)
- Recruitment Planning Guide (ORE, CLIN)
- Remuneration (ORE, CLIN)
Biospecimen Acquisition, Processing, and Storage
These resources cover standardized collection, handling, and storage of biological specimens.
- Biomarker Collection, Processing and Storage - Blood (BIO)
- Biomarker Collection, Processing and Storage - CSF (BIO)
- Brain* (NP)
- Cost Recovery* (ADMIN)
- DNA / RNA / Protein* (GEN)
- Material Transfer* (ADMIN)
Neuropathology
These resources support postmortem tissue workflows and digital pathology infrastructure.
- Brain* (NP)
- Clinicopathology Case Conference (CPC) Videos for Education (REC, NP) (includes Sample Consent Form)
- Digital Neuropathology* (NP)
Data Management, Informatics, and Study Quality
These resources address data infrastructure, sharing practices, and standards for research rigor.
- Guidance for Management & Sharing (DATA)
- Informatics* (DATA)
- Intellectual Property* (ADMIN)
- Rigor and Reproducibility (REC, DATA)
Outreach, Recruitment, and Community Engagement
These resources support community-based participation and engagement with state and federal stakeholders.
- Engaging Support at the Federal Level (ADMIN, ORE)
- Engaging Support at the State Level (ADMIN, ORE)
- National Strategy (ORE)
- Recruitment Planning Guide (ORE, CLIN)
Center Administration and Governance
These resources address institutional operations, oversight, and planning.
- EAC Guidelines* (ADMIN)
- Succession Planning for ADRCs (ADMIN)
* Included in the original working group guidance. A single PDF of the collected working group guidance is available for reference here.