2022 Spring ADRC Meeting
The Spring 2022 ADRC Meeting was held in a Hybrid format, online and in-person in Los Angeles, CA. Links to slides and video recordings are below.
View the final agenda in full.
Imaging Core Session
View and Download Slide Presentations:
- Introduction
- Beth Mormino, PhD, Stanford ADRC
- NACC Imaging Update
- Sarah Biber, PhD, NACC
- SCAN Updates
- Clifford R. Jack Jr., MD, Mayo Clinic ADRC
- ADRC consortium for CLarity in ADRD Research Through Imaging (CLARiTI)
- Sterling Johnson, PhD, Wisconsin ADRC
- SCAN Amyloid Legacy Project
- Beth Mormino, PhD, Stanford ADRC
- MRI Legacy Project
- Charlie Decarli, MD, UC Davis ADRC
- Imaging Prodromal DLB
- Kejal Kantarci, MD, MS, Mayo Clinic ADRC
- Tau PET quantification across ligands
- Victor Villemange, MD, Pittsburg ADRC
- Tau PET disclosure
- Annalise Rahman-Filipiak, PhD, Michigan ADRC
- Introduction
- Beth Mormino, PhD, Stanford ADRC
- NACC Imaging Update
- Sarah Biber, PhD, NACC
- SCAN Updates
- Clifford R. Jack Jr., MD, Mayo Clinic ADRC
- ADRC consortium for CLarity in ADRD Research Through Imaging (CLARiTI)
- Sterling Johnson, PhD, Wisconsin ADRC
- SCAN Amyloid Legacy Project
- Beth Mormino, PhD, Stanford ADRC
- MRI Legacy Project
- Charlie Decarli, MD, UC Davis ADRC
- Imaging Prodromal DLB
- Kejal Kantarci, MD, MS, Mayo Clinic ADRC
- Tau PET quantification across ligands
- Victor Villemange, MD, Pittsburg ADRC
- Tau PET disclosure
- Annalise Rahman-Filipiak, PhD, Michigan ADRC
Clinical Core Session
View and Download Slide Presentations:
- Mitochondria and Bioenergetics in AD: Why We Should Care
- Jeffrey Burns, MD, Univ of Kansas
- Setting the Stage: Mitochondria, Bioenergetics and The Road to AD
- Russel Swerdlow, MD, Univ of Kansas
- TREAT-AD Informatics Pipeline Converges Upon Mitochondrial Function as an Early Key Element of AD Pathology.
- Jesse Wiley, PhD, MS, Sage Bionetworks
- Integrated Proteomics Reveals CSF Biomarkers linked to Metabolism in AD
- Nicholas Seyfried, PhD, Emory University SOM
- Mitochondrial polygenic risk scores for Alzheimer’s Disease
- Shea Andrews, PhD, Icahn SOM, Mount Sinai
- Mitochondrial DNA Quantity and Quality in Aging and AD
- Hans Klein, PhD, Columbia University
- ApoE and Mitochondria
- Robert Mahley, MD, PhD, Gladstone Institutes; UCSF
- Bioenergetic dysfunction in neurodegenerative dementias: How mitochondrial PET imaging can help elucidate pathogenic pathways in AD and DLB
- Sarah Berman, MD, PhD, Univ of Pittsburgh ADRC
- Amyloid Precursor Protein and Mitochondria
- Heather Wilkins, PhD, Univ of Kansas ADRC
- Mitochondria Targeted Therapeutics for Alzheimer's Disease: The Good. The Bad. The Potential.
- Roberta Diaz Brinton, PhD, Arizona ADRC
- Mitochondria and Bioenergetics in AD: Why We Should Care
- Jeffrey Burns, MD, Univ of Kansas
- Setting the Stage: Mitochondria, Bioenergetics and The Road to AD
- Russel Swerdlow, MD, Univ of Kansas
- TREAT-AD Informatics Pipeline Converges Upon Mitochondrial Function as an Early Key Element of AD Pathology.
- Jesse Wiley, PhD, MS, Sage Bionetworks
- Integrated Proteomics Reveals CSF Biomarkers linked to Metabolism in AD
- Nicholas Seyfried, PhD, Emory University SOM
- Mitochondrial polygenic risk scores for Alzheimer’s Disease
- Shea Andrews, PhD, Icahn SOM, Mount Sinai
- Mitochondrial DNA Quantity and Quality in Aging and AD
- Hans Klein, PhD, Columbia University
- ApoE and Mitochondria
- Robert Mahley, MD, PhD, Gladstone Institutes; UCSF
- Bioenergetic dysfunction in neurodegenerative dementias: How mitochondrial PET imaging can help elucidate pathogenic pathways in AD and DLB
- Sarah Berman, MD, PhD, Univ of Pittsburgh ADRC
- Amyloid Precursor Protein and Mitochondria
- Heather Wilkins, PhD, Univ of Kansas ADRC
- Mitochondria Targeted Therapeutics for Alzheimer's Disease: The Good. The Bad. The Potential.
- Roberta Diaz Brinton, PhD, Arizona ADRC
Clinical Core Virtual Data Blitz
View and Download Slide Presentations:
- A Mitochondrial Complex I Defficiency Induces O2-Dependent Tau Aggregation
- Anthony S. Grillo, PhD
- Association of Mitochondrial DNA Copy Number with Brain MRI Markers and Cognitive Function in TOPMed Cohorts
- Claudia Satizabal, PhD
- Mitophagy alterations are early and prominent features of Alzheimer’s disease and related dementias
- Wolfdieter Springer, PhD
- Potential Role of Mitochondria in the Activity of Inflammatory-Responsive MicroRNAs
- Wang-Xia Wang, PhD
- APOE4 Mediates Abnormal Mitochondira-Endolysosomal Contacts in Alzheimer's Disease
- Wenzhang Wang, PhD
- A Mitochondrial Complex I Defficiency Induces O2-Dependent Tau Aggregation
- Anthony S. Grillo, PhD
- Association of Mitochondrial DNA Copy Number with Brain MRI Markers and Cognitive Function in TOPMed Cohorts
- Claudia Satizabal, PhD
- Mitophagy alterations are early and prominent features of Alzheimer’s disease and related dementias
- Wolfdieter Springer, PhD
- Potential Role of Mitochondria in the Activity of Inflammatory-Responsive MicroRNAs
- Wang-Xia Wang, PhD
- APOE4 Mediates Abnormal Mitochondira-Endolysosomal Contacts in Alzheimer's Disease
- Wenzhang Wang, PhD
Administrators Session
View and Download Slide Presentations:
- Welcome new Administrators!
- Karyn Marsh, PhD, NYU ADRC
- External Advisory Boards: Post-COVID Realities
- Annika Noreen, PhD, PMP, Univ of Washington ADRC
- Clinical Research Operations and Management System (CROMS)
- Arijit Bhaumik, CCRP, Michigan ADRC
- Remote Retention and Engagement Strategies Across ADRCs
- Hanna Blazel, MS, CCC-SLP & Dorothy Farrar-Edwards, PhD, Wisconsin ADRC
- Welcome new Administrators!
- Karyn Marsh, PhD, NYU ADRC
- External Advisory Boards: Post-COVID Realities
- Annika Noreen, PhD, PMP, Univ of Washington ADRC
- Clinical Research Operations and Management System (CROMS)
- Arijit Bhaumik, CCRP, Michigan ADRC
- Remote Retention and Engagement Strategies Across ADRCs
- Hanna Blazel, MS, CCC-SLP & Dorothy Farrar-Edwards, PhD, Wisconsin ADRC
REC Session
View and Download Slide Presentations:
- REC Update Part 1: Collaboration and Support
- Hussein Yassine, MD, USC ADRC
- REC Update Part 2: Diversity Workgroup
- Barbara Bendlin, PhD, Wisconsin ADRC
- REC Update Part 1: Collaboration and Support
- Hussein Yassine, MD, USC ADRC
- REC Update Part 2: Diversity Workgroup
- Barbara Bendlin, PhD, Wisconsin ADRC
REC Scholar Presentations
Congratulations to the REC Rising Star Awardees: Miranda Lim, MD, PhD, Oregon ADRC and Nicole Rogus-Pulia, PhD, CCC-SLP, Wisconsin ADRC.
View and Download Slide Presentations:
- Untangling the Association of Tau and Synaptic Changes in Aging and Alzheimer's Disease
- Meaghan Morris, MD, PhD, John Hopkins ADRC
- Development of a Home-Based Stress Management Toolkit for Dementia Caring Dyads
- Melissa Harris, PhD, RN, Duke Univ of NC-Chapel Hill ADRC
- Clinician Perspectives on Use of Plasma Alzheimer's Disease Biomarkers in Primary Care
- Kyra O’Brien, MD, Univ of Pennsylvania
- Blue autofluorescence imaging reveals retinal inclusion bodies in cognitively unimpaired older adults at high risk for Alzheimer's disease
- Edmund Arthur, OD, PhD, FAA, Univ of Alabama ADRC
- Cellular Senescence as a Novel Therapeutic Target for Treating Mild Cognitive Impairment and Early Alzheimer's Disease
- Miranda E. Orr, PhD, Wake Forest ADRC
- Investigation of Genetic Signatures of Primary Age-Related Tauopathy
- Kurt Farrell, PhD, Mount Sinai ADRC
- Between Here and There: Addressing End of Life Disparities Among African Americans with Mild Cognitive Impairment and Dementia Through Community-Based Training in Advanced Care Planning
- Maisha Robinson, MD, MSHPM, Mayo Clinic ADRC - Florida
- Arterial Aging & Brain Health in Older Adults
- Francis Cambonero, BS, Vanderbilt ADRC
- Moving Beyond Reactive Approaches: A Paradigm Shift in Dysphagia Management for Persons with Alzheimer's Disease
- Nicole Rogus-Pulia, PhD, CCC-SLP, Wisconsin ADRC
- Molecular features of amyloid-β and tau in CTE with Alzheimer's disease copathology
- Ignazio Cali, PhD, Cleveland ADRC
- Perspectives on Alzheimer's Disease Biomarker Disclosure among Racially Diverse Older Adults
- Annalise Rahman-Filipiak, PhD, Michigan ADRC
- A Ketogenic Diet Differentially Affects Neuron and Astrocyte Transcription: Implications for the Treatment of Alzheimer's Disease
- Scott Koppel, BS, Univ of Kansas ADRC
- Challenges Associated with Remote Caregiving and a Proposed Solution
- Alyssa Weakley, PhD, Univ of California Davis ADRC
- Identification of genetic regions associated with p-tau blood concentration on the Hispanic population
- Marcio Almeida, PhD, South Texas ADRC
- Data-Driven Stratification of Neurodegenerative Disorders Using Video-MRI Analysis
- Ehsan Adeli, PhD, Stanford ADRC
- TWLITE (Tunable White Light Therapy in Elders to improve sleep): An ORCATECH Life Lab Pilot Study
- Miranda Lim, MD, PhD, Oregon ADRC
- Molecular insights into the phase transition behavior of neurodegenerative disease related proteins
- Galia Debelouchina, PhD, UCSD Shiley-Marcos ADRC
- Untangling the Association of Tau and Synaptic Changes in Aging and Alzheimer's Disease
- Meaghan Morris, MD, PhD, John Hopkins ADRC
- Development of a Home-Based Stress Management Toolkit for Dementia Caring Dyads
- Melissa Harris, PhD, RN, Duke Univ of NC-Chapel Hill ADRC
- Clinician Perspectives on Use of Plasma Alzheimer's Disease Biomarkers in Primary Care
- Kyra O’Brien, MD, Univ of Pennsylvania
- Blue autofluorescence imaging reveals retinal inclusion bodies in cognitively unimpaired older adults at high risk for Alzheimer's disease
- Edmund Arthur, OD, PhD, FAA, Univ of Alabama ADRC
- Cellular Senescence as a Novel Therapeutic Target for Treating Mild Cognitive Impairment and Early Alzheimer's Disease
- Miranda E. Orr, PhD, Wake Forest ADRC
- Investigation of Genetic Signatures of Primary Age-Related Tauopathy
- Kurt Farrell, PhD, Mount Sinai ADRC
- Between Here and There: Addressing End of Life Disparities Among African Americans with Mild Cognitive Impairment and Dementia Through Community-Based Training in Advanced Care Planning
- Maisha Robinson, MD, MSHPM, Mayo Clinic ADRC - Florida
- Arterial Aging & Brain Health in Older Adults
- Francis Cambonero, BS, Vanderbilt ADRC
- Moving Beyond Reactive Approaches: A Paradigm Shift in Dysphagia Management for Persons with Alzheimer's Disease
- Nicole Rogus-Pulia, PhD, CCC-SLP, Wisconsin ADRC
- Molecular features of amyloid-β and tau in CTE with Alzheimer's disease copathology
- Ignazio Cali, PhD, Cleveland ADRC
- Perspectives on Alzheimer's Disease Biomarker Disclosure among Racially Diverse Older Adults
- Annalise Rahman-Filipiak, PhD, Michigan ADRC
- A Ketogenic Diet Differentially Affects Neuron and Astrocyte Transcription: Implications for the Treatment of Alzheimer's Disease
- Scott Koppel, BS, Univ of Kansas ADRC
- Challenges Associated with Remote Caregiving and a Proposed Solution
- Alyssa Weakley, PhD, Univ of California Davis ADRC
- Identification of genetic regions associated with p-tau blood concentration on the Hispanic population
- Marcio Almeida, PhD, South Texas ADRC
- Data-Driven Stratification of Neurodegenerative Disorders Using Video-MRI Analysis
- Ehsan Adeli, PhD, Stanford ADRC
- TWLITE (Tunable White Light Therapy in Elders to improve sleep): An ORCATECH Life Lab Pilot Study
- Miranda Lim, MD, PhD, Oregon ADRC
- Molecular insights into the phase transition behavior of neurodegenerative disease related proteins
- Galia Debelouchina, PhD, UCSD Shiley-Marcos ADRC
Directors Session
View and Download Slide Presentations:
- Alzheimer’s Disease and AD Related Dementias Research: Policy and Program Updates
- Richard Hodes, MD, NIA/NIH
- Honoring Dr. John Trojanowski: Honoring John as a person
- David Wolk, MD, Penn ADRC / Penn Memory Center
- Honoring Dr. John Trojanowski: John Q. Trojanowski: Insights and Impact
- Edward Lee, MD, PhD, Penn ADRC / Penn Memory Center
- Appreciation of John Trojanowski and age related TDP-43 pathology (LATE)
- Peter Nelson, MD, PhD, Univ of Kentucky ADRC, Sanders-Brown Center
- Tau protein as a therapeutic target and biomarker for neurologic disease (and JQT)
- Adam Boxer, MD, PhD, UCSF ADRC
- Evaluation of Blood-Based, Exosome Cargo as Biomarkers for AD and Other Neurodegenerative Diseases
- Charisse Winston-Gray, PhD, UCSD Shiley-Marcos ADRC
- Alzheimer’s Disease and AD Related Dementias Research: Policy and Program Updates
- Richard Hodes, MD, NIA/NIH
- Honoring Dr. John Trojanowski: Honoring John as a person
- David Wolk, MD, Penn ADRC / Penn Memory Center
- Honoring Dr. John Trojanowski: John Q. Trojanowski: Insights and Impact
- Edward Lee, MD, PhD, Penn ADRC / Penn Memory Center
- Appreciation of John Trojanowski and age related TDP-43 pathology (LATE)
- Peter Nelson, MD, PhD, Univ of Kentucky ADRC, Sanders-Brown Center
- Tau protein as a therapeutic target and biomarker for neurologic disease (and JQT)
- Adam Boxer, MD, PhD, UCSF ADRC
- Evaluation of Blood-Based, Exosome Cargo as Biomarkers for AD and Other Neurodegenerative Diseases
- Charisse Winston-Gray, PhD, UCSD Shiley-Marcos ADRC
Biomarker Core Session
View and Download Slide Presentations:
- Goals of the committee and the Biomarker Cores at ADRCs
- Cerise Elliott, PhD, NIA/NIH
- Short Report: NACC CSF Aβ42, p-Tau181, t-Tau
- Lynn Bekris, PhD, Cleveland ADRC
- Blood-Based Biomarkers for Alzheimer’s disease
- Jeff Dage, PhD, Indiana University ADRC
- Best Practices & Pre-Analytical
- Donna Wilcock, PhD, Kentucky ADRC
- Round Table Panel Discussion
- Thomas Wingo, MD, Emory University, Goizueta ADRC
- Goals of the committee and the Biomarker Cores at ADRCs
- Cerise Elliott, PhD, NIA/NIH
- Short Report: NACC CSF Aβ42, p-Tau181, t-Tau
- Lynn Bekris, PhD, Cleveland ADRC
- Blood-Based Biomarkers for Alzheimer’s disease
- Jeff Dage, PhD, Indiana University ADRC
- Best Practices & Pre-Analytical
- Donna Wilcock, PhD, Kentucky ADRC
- Round Table Panel Discussion
- Thomas Wingo, MD, Emory University, Goizueta ADRC
Digital Biomarker / CTF Tech Session
View and Download Slide Presentations: